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Selected Publications
2020 - Present

Klf5 establishes bi-potential cell fate by dual regulation of ICM and TE specification genes

Kinisu M*, Choi YJ*, Cattoglio C, Liu K,  Roux de Bezieux H, Valbuena R, Pum N, Dudoit S, Huang H, Xuan Z, Kim SY, He L. . Cell reports, in press. bioRxiv 2021.06.02.446799; doi:


A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development.

Modzelewski AJ, Shao W, Chen J, Lee A, Qi X, Noon M, Tjokro K, Sales G, Biton A, Anand A, Speed TP, Xuan Z, Wang T, Risso D, He L. Cell. 2021 Oct 28;184(22):5541-5558.e22. doi: 10.1016/j.cell.2021.09.021. Epub 2021 Oct 12. PMID: 34644528; PMCID: PMC8787082.


miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts.

Xue B, Chuang CH, Prosser HM, Fuziwara CS, Chan C, Sahasrabudhe N, Kühn M, Wu Y, Chen J, Biton A, Chen C, Wilkinson JE, McManus MT, Bradley A, Winslow MM, Su B, He L.  Genes Dev. 2021 Aug 1;35(15-16):1109-1122. doi: 10.1101/gad.347344.120. Epub 2021 Jul 22. PMID: 34301766; PMCID: PMC8336896.

Multimodal detection of protein isoforms and nucleic acids from mouse preimplantation embryos.
Elisabet Rosàs-Canyelles*, Andrew J Modzelewski*, Alisha Geldert, Lin He, Amy E Herr. Nature Protocols , 2021 Feb;16(2):1062-1088. DOI: 10.1038/s41596-020-00449-2. Epub 2021 Jan 15.

Assessing heterogeneity among single embryos and single blastomeres using open microfluidic design.

Rosàs-Canyelles E, Modzelewski AJ, Geldert A, He L, Herr AE. Sci Adv. 2020 Apr 22;6(17):eaay1751. doi: 10.1126/sciadv.aay1751. PMID: 32494630; PMCID: PMC7176412.

2015 - 2020

CRISPR-READI: Efficient generation of knock-in mice by CRISPR RNP Electroporation and AAV Donor Infection. Chen S., Sun S., Schaffer D., and He L. Cell reports, 2019 Jun 25;27(13):3780-3789.e4. doi: 10.1016/j.celrep.2019.05.103.

Efficient mouse genome engineering by CRISPR-EZ technologyModzelewski AJ*, Chen S*, Willis BJ, Lloyd KCK, Wood JA and He L. Nature Protocols, 2018, Jun;13(6):1253-1274. doi: 10.1038/nprot.2018.012. Epub 2018 May 10.

A lncRNA fine tunes the dynamics of a cell state transition involving Lin28-let7 and de novo DNA methylation. Li MA#, Amaral PP, Cheung P, Bergmann JH, Kinoshita M, Kalkan T, Ralser M, Robson S, von Meyenn F, Paramor M, Yang F, Chen C, Nichols J, Spector D, Kouzarides T, He L#, Smith A #.  Elife, 2017, Aug 18;6. pii: e23468. doi: 10.7554/eLife.23468.  

A Hox-Embedded Long Noncoding RNA: Is It All Hot Air? Selleri L, Bartolomei MS, Bickmore WA, He L, Stubbs L, Reik W, Barsh GS.  PLoS Genetics 2016 Dec 15;12(12):e1006485. doi: 10.1371/journal.pgen.1006485. 


Deficiency of miRNA miR-34a expands cell fate potential of pluripotent stem cellsChoi YJ*, Lin CP*#, Risso D*, Chen S, Kim TA, Tan M, Li JB, Wu Y, Chen C, Xuan Z, MacFarlan T, Peng W, Lloyd KC, Kim SY, Speed TP, He L#. Deficiency of miRNA miR-34a expands cell fate potential of pluripotent stem cells. Science, (research article) , 2017  Feb 10;355(6325).

ighly Efficient Mouse Genome Editing by CRISPR Ribonucleoprotein Electroporation of Zygotes. Chen S, Lee B, Lee A, Modzelewski A# and He L#. H J. Biol Chem  2016 May 5. pii: jbc.M116.733154.


Outside the coding genome, microRNAs make a big difference.
Olive V, Sabio E, Minella AC and He L.  Science Signaling, Sci Signal. 2015 Mar 17;8(368):re2.

2010 - 2015

miR-34/449 miRNAs are required for motile ciliogenesis by repressing Cp110.Song R*#, Walentek P*, Sponer N*, Lize M, Klimke A, Lee JS, Dixon GR, Lishko P, Kessel M, He L#.  Nature (Research article), 2014 Jun 5;510(7503):115-20. 


MiR-34a blocks Osteoporosis and Bone Metastasis by Inhibiting Osteoclastogenesis and Tgif2.
Krzeszinski JY, Wei W, Huynh H, Jin Z, Chang T, Xie X, He L, Lingegowda MS, Lopez-Berestein G, Sood AK, Mendell JT and Wan Y.  Nature, 2014 Aug 28;512(7515):431-5. 

An expanding universe of the non-coding genome in cancer biology

Xue B and He L.  Carcinogenesis, 2014 Jun;35(6):1209-1216. Epub 2014 Apr 18.


A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression
Okada N, Ribeiro M, Biton A, Lin C, Lai G, Bu P, Vogel H, Jablons DM , Keller A, Wilkinson JE, He B, Speed TP and He L.  Genes and Development, 2014 Mar 1;28(5):438-50. doi: 10.1101/gad.233585.113.

A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.
Olive V*, Sabio E*, Bennett M, De Jong C, Biton A, McGann JC, Greaney SK, Sodir NM, Zhou AY, Balakrishnan A, Foth M, Luftig M, Goga A, Speed TP, Xuan Z, Evan G, Wan Y, Minella A, He L. Elife. 2013 Oct 15;2:e00822. doi: 10.7554/eLife.00822. PMID: 24137534


The emerging functions of the p53-miRNA network in stem cell biology.
Lin C, Choi Y, Hicks GG and He L.   Cell Cycle, 2012 Jun 1;11(11). PMID: 22580472.

miR-34a miRNA provides a barrier for somatic cell reprogramming.
Choi Y*, Lin C*, Zhong Y, He X, Kim S, Okada N, Bu P, Bennett MJ, Chen C, Ozturk A, Hicks G, Hannon GJ, and He L.  Nature Cell Biology, 2011 Oct 23;13(11):1353-60. PMID: 22020437.

Post-transcriptional regulation of PTEN dosage by non-coding RNAs.
He L. Science Signaling 2010 Nov 2;3(146):pe39. PMID: 21045203.

2010 - 2015

Olive V *, Bennett MJ*, Walker JC, Ma C, Jiang I, Cordon-Cardo C, Li Q, Lowe SW, Hannon GJ#  and He L#. miR-19 is a key oncogenic component of mir-17-92. Genes and Development 2009 Dec 15;23(24):2839-49. PMID: 20008935.

He L, He X, Lowe SW and Hannon GJ. microRNAs join the p53 pathway, another piece of the tumor suppressor puzzle. Nat Rev Cancer. 2007 Nov;7(11):819-22.

He L*, He X*, Lim LP, de Stanchina E, Xuan Z, Liang Y, Xue W, Zender L, Magnus J, Ridzon D, Jackson AL, Linsley PS, Chen C, Lowe SW, Cleary MA# and Hannon GJ#. A microRNA component of the p53 tumour suppressor network. Nature. 2007 Jun 28;447(7148):1130-4.

He L*, Thomson JM*, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ# and Hammond SM#. A microRNA polycistron as a potential human oncogene. Nature. 2005 Jun9; 435(7043):828-33.

He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet. 2004 Jul;5(7):522-31.

He L, Eldredge AG, Jackson PK, Gunn TM, Barsh GS. Accessory proteins for melanocortin signaling: attractin and mahogunin. Ann N Y Acad Sci. 2003 Jun;994:288-98.

He L, Lu XY, Jolly AF, Eldridge AG, Watson SJ, Jackson PK, Barsh GS# and Gunn TM#. Spongiform encephalopathy caused by defects of an E3 ubiquitin ligase in mahoganoid mice. Science, 2003 Jan 31;299(5607):710-2.

He L*, Gunn TM*, Bouley DM, Lu XY, Watson SJ, Schlossman SF, Duke-Cohan JS, Barsh GS. A biochemical function for attractin in agouti-induced pigmentation and obesity. Nat Genet. 2001 Jan;27(1):40-7.

Gunn TM, Miller KA, He L, Hyman RW, Davis RW, Azarani A, Schlossman SF, Duke-Cohan JS, Barsh GS. The mouse mahogany locus encodes a transmembrane form of human attractin. Nature 1999 Mar 11;398(6723):152-6.

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